E-mail

E-mail a Wiley Online Library Link

Dr. Vinod Puthan Veetil, Hans Raj, Dr. Marianne de Villiers, Pieter G. Tepper, Prof. Dr. Frank J. Dekker, Prof. Dr. Wim J. Quax and Prof. Dr. Gerrit J. Poelarends Enantioselective Synthesis of N-Substituted Aspartic Acids Using an Engineered Variant of Methylaspartate Ammonia Lyase ChemCatChem 5

Article first published online: 7 MAR 2013 | DOI: 10.1002/cctc.201200906

Thumbnail image of graphical abstract

Unnatural reactions: We report the synthesis of a large variety of N-substituted aspartic acids by addition of structurally diverse amines to fumaric acid; the reactions are catalyzed by a previously engineered variant of methylaspartate ammonia lyase. The additions are highly enantioselective and yield only the L enantiomers of the corresponding amino acid products (>99 % ee).

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH