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Dr. Vinod Puthan Veetil, Hans Raj, Dr. Marianne de Villiers, Pieter G. Tepper, Prof. Dr. Frank J. Dekker, Prof. Dr. Wim J. Quax and Prof. Dr. Gerrit J. Poelarends Enantioselective Synthesis of N-Substituted Aspartic Acids Using an Engineered Variant of Methylaspartate Ammonia Lyase ChemCatChem 5

Version of Record online: 7 MAR 2013 | DOI: 10.1002/cctc.201200906

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Unnatural reactions: We report the synthesis of a large variety of N-substituted aspartic acids by addition of structurally diverse amines to fumaric acid; the reactions are catalyzed by a previously engineered variant of methylaspartate ammonia lyase. The additions are highly enantioselective and yield only the L enantiomers of the corresponding amino acid products (>99 % ee).

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