Dr. María Pérez-Sánchez, Christoph R. Müller and Dr. Pablo Domínguez de María Multistep Oxidase–Lyase Reactions: Synthesis of Optically Active 2-Hydroxyketones by Using Biobased Aliphatic Alcohols ChemCatChem 5
From natural sources: The utilization of (biobased) aliphatic alcohols for the in situ enzymatic production of aldehydes and the subsequent lyase-catalyzed carboligation is explored for the production of α-hydroxyketones, which are valuable building blocks in organic synthesis. The reactions proceed with high conversion and enantioselectivity and are performed in an integrative manner. BAL=benzaldehyde lyase, FAD=flavin adenine dinucleotide.
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