Dr. Caroline E. Paul, Dr. Iván Lavandera, Dr. Vicente Gotor-Fernández, Prof. Wolfgang Kroutil and Prof. Vicente Gotor Escherichia coli/ADH-A: An All-Inclusive Catalyst for the Selective Biooxidation and Deracemisation of Secondary Alcohols ChemCatChem 5
An integrated recycling system: A nicotinamide adenine dinucleotide regeneration system present in Escherichia coli cells is exploited for the oxidation of secondary alcohols with E. coli/alcohol dehydrogenase (ADH-A). Racemic alcohols are oxidized selectively without need for an external cofactor or cosubstrate, which affords the remaining enantioenriched (R)-alcohols. Deracemization, desymmetrization, and stereoinversion processes are developed, which leads to optically pure high value-added compounds.
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