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Nikolin Oberleitner, Christin Peters, Jan Muschiol, Dr. Maria Kadow, Stefan Saß, Thomas Bayer, Patricia Schaaf, Dr. Naseem Iqbal, Dr. Florian Rudroff, Prof. Dr. Marko D. Mihovilovic and Prof. Dr. Uwe T. Bornscheuer An Enzymatic Toolbox for Cascade Reactions: A Showcase for an In Vivo Redox Sequence in Asymmetric Synthesis ChemCatChem 5

Version of Record online: 13 SEP 2013 | DOI: 10.1002/cctc.201300604

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Joined forces: Alcohol dehydrogenase, enoate reductase, and Baeyer–Villiger monooxygenase are combined in a cascade reaction by coexpression in E. coli to have a recombinant whole-cell biocatalyst. Such an artificial metabolic “mini”-pathway provides access to functionalized chiral compounds in high yields and optical purities as exemplified for kinetic resolutions, desymmetrizations, and regiodivergent biotransformations.

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