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Prof. Dr. Thomas Brück, Prof. Dr. Robert Kourist and Dr. Bernhard Loll Production of Macrocyclic Sesqui- and Diterpenes in Heterologous Microbial Hosts: A Systems Approach to Harness Nature’s Molecular Diversity ChemCatChem 6

Article first published online: 26 MAR 2014 | DOI: 10.1002/cctc.201300733

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Celling it: Natural products macrocyclic sesqui- (C15) and diterpenes (C20) have anticancer, antimicrobial, and insecticidal properties. To overcome the difficulties in synthesizing these complex structures, heterologous production in recombinant whole-cell biocatalysts is emerging. Metabolic, enzyme, and process engineering and systems biology have recently led to significant improvements towards economically viable processes. GGPPS=geranylgeranyl diphosphate.

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