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Tommaso Quinto, Fabian Schwizer, Dr. Jeremy M. Zimbron, Albert Morina, Dr. Valentin Köhler and Prof. Dr. Thomas R. Ward Expanding the Chemical Diversity in Artificial Imine Reductases Based on the Biotin–Streptavidin Technology ChemCatChem 6

Article first published online: 16 JAN 2014 | DOI: 10.1002/cctc.201300825

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Biotinspired! A new strategy for the generation of chemical diversity in artificial transfer hydrogenases (ATHases) based on the biotin–streptavidin technology is disclosed. By combining a biotinylated MCp* fragment with 34 commercially available ligands in the presence of wild-type streptavidin, promising candidates for the asymmetric reduction of imines are identified. Selected ligands are screened against 21 streptavidin isoforms and the performance of the resulting constructs is evaluated.

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