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Kinga Kędziora, Dr. Fabricio R. Bisogno, Dr. Iván Lavandera, Dr. Vicente Gotor-Fernández, Dr. Jose Montejo-Bernardo, Prof. Santiago García-Granda, Prof. Wolfgang Kroutil and Prof. Vicente Gotor Expanding the Scope of Alcohol Dehydrogenases towards Bulkier Substrates: Stereo- and Enantiopreference for α,α-Dihalogenated Ketones ChemCatChem 6

Version of Record online: 12 FEB 2014 | DOI: 10.1002/cctc.201300834

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Bulking up: A series of β,β-dihalohydrins are obtained through alcohol dehydrogenase (ADH) catalyzed bioreduction of the synthesized α,α-dihalogenated ketones. Two racemic acetophenone derivatives are also subjected to this protocol to obtain stereoenriched alcohols through dynamic kinetic resolution (DKR).

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