Dr. Selin Kara, Dominik Spickermann, Dr. Andrea Weckbecker, Dr. Christian Leggewie, Prof. Dr. Isabel W. C. E. Arends and Dr. Frank Hollmann Bioreductions Catalyzed by an Alcohol Dehydrogenase in Non-aqueous Media ChemCatChem 6
Practical water-deficient enzymology for bioreductions: The use of alcohol dehydrogenases (ADHs) in neat substrates and in water-immiscible organic solvents is explored. The ADH evo-1.1.200 excelled by its high stability, as it showed significant catalytic activity over days. Reductions are coupled with the “smart cosubstrate” 1,4-butanediol; hence, excess amounts of reductants are avoided.
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