Dr. Andreas Vogel, Dr. Ramona Schmiedel, Dr. Ute Hofmann, Prof. Karl Gruber and Prof. Klaus Zangger Converting Aspartase into a β-Amino Acid Lyase by Cluster Screening ChemCatChem 6
β-Amino acids with aspartase mutants: Aspartase, despite being one of the most specific enzymes known, shows potential for application in β-amino acid synthesis. By applying a combination of focused library design and cluster screening, we created an aspartate mutant with β-amino acid lyase activity and thus open up a new platform to synthesize this interesting and important compound class. BSASP-C6= Mutant of AspB from Bacillus sp. YM55-1.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf