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Dr. Andreas Vogel, Dr. Ramona Schmiedel, Dr. Ute Hofmann, Prof. Karl Gruber and Prof. Klaus Zangger Converting Aspartase into a β-Amino Acid Lyase by Cluster Screening ChemCatChem 6

Version of Record online: 1 APR 2014 | DOI: 10.1002/cctc.201300986

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β-Amino acids with aspartase mutants: Aspartase, despite being one of the most specific enzymes known, shows potential for application in β-amino acid synthesis. By applying a combination of focused library design and cluster screening, we created an aspartate mutant with β-amino acid lyase activity and thus open up a new platform to synthesize this interesting and important compound class. BSASP-C6= Mutant of AspB from Bacillus sp. YM55-1.

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