Magnus Fransson, Jonas Johansson, Anders Sparén and Olof Svensson Comparison of multivariate methods for quantitative determination with transmission Raman spectroscopy in pharmaceutical formulations Journal of Chemometrics 24
The use of transmission Raman spectroscopy for quantitative assessment of pharmaceutical tablets, with variation in paracetamol content, using different multivariate approaches was investigated. The different multivariate models resulted in calibration errors between 2.4 and 6.5%. Models based on only two concentration levels (4 samples) resulted in almost as good results as if 9 concentration levels (18 samples) were used in the calibration. All calibration models were easy to interpret because of the selective Raman spectra.
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