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M. I. Osorio-Garcia, D. M. Sima, F. U. Nielsen, U. Himmelreich and S. Van Huffel Quantification of magnetic resonance spectroscopy signals with lineshape estimation Journal of Chemometrics 25

Article first published online: 4 MAR 2011 | DOI: 10.1002/cem.1353

Quantification of magnetic resonance spectroscopy (MRS) signals is required for providing metabolite concentrations of the tissue under investigation. However, inhomogeneities of the static magnetic field and tissue heterogeneities affect the lineshape of MRS signals and thus quantification. We propose an extension of the self-deconvolution method, by estimating and smoothing a common lineshape using a robust method with local regression. This common lineshape is imposed in the metabolite quantification method and the spectral parameters are obtained via nonlinear least squares.

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