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Katrin Lundstedt-Enkel, Daniel Karlsson and Per Ola Darnerud Interaction study with rats given two flame retardants: polybrominated diphenyl ethers (Bromkal 70-5 DE) and chlorinated paraffins (Cereclor 70L) Journal of Chemometrics 24

Article first published online: 30 NOV 2010 | DOI: 10.1002/cem.1354

Female Sprague-Dawley rats were given (by gavage) 2 flame retardants that are common in the environment; one, a mixture of polybrominated diphenyl ethers and the other a mixture of chlorinated paraffins. Doehlert design was used to select the concentrations. Several endpoints were measured and we show that hepatic enzyme activities were induced while plasma thyroxine decreased. Notably, the exposure combination causing the most marked effects represented intermediate doses of both substances.

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