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Carin Andersson, Katrin Lundstedt-Enkel, Ioanna Katsiadaki, William V. Holt, Katrien J.W. Van Look and Jan Örberg A chemometrical approach to study interactions between ethynylestradiol and an AhR-agonist in stickleback (Gasterosteus aculeatus) Journal of Chemometrics 24

Version of Record online: 29 DEC 2010 | DOI: 10.1002/cem.1368

We show that Ethoxyresorufin-O-deethylase (EROD) activity in gill and liver as well as sperm quality in male three-spined stickleback (Gasterosteus aculeatus) is affected after co-exposure to 17α-ethynylestradiol (EE2) and the AhR-agonist β-naphthoflavone (BNF). If the capacity to induce gill EROD activity is a general property of estrogen acting chemicals, our finding is important. We suggest that a gill EROD assay could be used as a sensitive biomarker for biomonitoring purposes.

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