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Mauro Marigo, Anne Kjærsgaard, Karsten Juhl, Nicholas Gathergood and Karl Anker Jørgensen Direct Catalytic Asymmetric Mannich Reactions of Malonates and β-Keto Esters Chemistry - A European Journal 9

Article first published online: 16 MAY 2003 | DOI: 10.1002/chem.200204679

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Highly functionalized optically active compounds can be obtained with an activated α-imino ester in direct Mannich reactions catalyzed by chiral bisoxazoline copper(II) complexes malonates and β-ketoesters such as depicted.

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