Laia Espelt, Teodor Parella, Jordi Bujons, Conxita Solans, Jesús Joglar, Antonio Delgado and Pere Clapés Stereoselective Aldol Additions Catalyzed by Dihydroxyacetone Phosphate-Dependent Aldolases in Emulsion Systems: Preparation and Structural Characterization of Linear and Cyclic Iminopolyols from Aminoaldehydes Chemistry - A European Journal 9
Emulsion systems are useful reaction media for enzyme-catalyzed aldol reactions. The L-fructose-1,6-bisphosphate aldolase (RAMA) and recombinant L-rhamnulose-1-phosphate aldolase from E. coli (RhuA) catalyzed stereoselective aldol additions between DHAP and N-Cbz aminoaldehydes (see scheme). A description of the reactivity of the aldolases in emulsions and a detailed stereochemical analysis of both linear and cyclic iminocylitols is presented.
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