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Eva González-García, Virgil Helaine, Gérard Klein, Melanie Schuermann, Georg A. Sprenger, Wolf-Dieter Fessner and Jean-Louis Reymond Fluorogenic Stereochemical Probes for Transaldolases Chemistry - A European Journal 9

Version of Record online: 11 FEB 2003 | DOI: 10.1002/chem.200390110

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A fluorescence assay for probing the activity and stereoselectivity of transaldolases, which catalyze the stereoselective aldol coupling between dihydroxyacetone and α-hydroxyaldehydes, is demonstrated. It is based on synthetic probes that undergo selective retroaldolization with the enzymes to form a fluorescent product. These probes comprise the simple fructose analogue 1 and the stereoisomeric pair 2/3, which is used to measure the fructo/tagato-stereoselectivity of transaldolases.

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