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Tian-Yu Liu, Rui Li, Qian Chai, Jun Long, Bang-Jing Li, Yong Wu, Li-Sheng Ding and Ying-Chun Chen Enantioselective Michael Addition of α-Substituted Cyanoacetates to Vinyl Ketones Catalyzed by Bifunctional Organocatalysts Chemistry - A European Journal 13

Version of Record online: 13 OCT 2006 | DOI: 10.1002/chem.200600796

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Asymmetric organocatalysis: A highly enantioselective Michael addition of α-substituted cyanoacetates to vinyl ketones synergistically promoted by simple bifunctional thiourea/tertiary amine organocatalysts is described (see scheme). The biologically important β2,2-amino acid esters with various structures could be efficiently prepared from the chiral adducts.

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