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Martin H. Fechter, Karl Gruber, Manuela Avi, Wolfgang Skranc, Christian Schuster, Peter Pöchlauer, Kurt O. Klepp and Herfried Griengl Stereoselective Biocatalytic Synthesis of (S)-2-Hydroxy-2-Methylbutyric Acid via Substrate Engineering by Using “Thio-Disguised” Precursors and Oxynitrilase Catalysis Chemistry - A European Journal 13

Version of Record online: 17 JAN 2007 | DOI: 10.1002/chem.200601114

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Enantioselective enzyme-catalysed synthesis of (S)-2-hydroxy-2-methylbutanoic acid (3) obtained with 99 % ee from masked 2-butanone synthons (1 or 2) is described in an enzymatic cyanohydrin reaction applying the hydroxynitrile lyase (HNL) from Hevea brasiliensis.

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