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Alois Fürstner, Melanie Bonnekessel, Jarred T. Blank, Karin Radkowski, Günter Seidel, Fabrice Lacombe, Barbara Gabor and Richard Mynott Total Synthesis of Myxovirescin A1 Chemistry - A European Journal 13

Version of Record online: 4 SEP 2007 | DOI: 10.1002/chem.200700926

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A convergent total synthesis of the antibiotic macrolide myxovirescin A1 is described that is largely based on reagent- and catalyst-controlled transformations. This includes a highly regioselective Negishi reaction of a dibromo-alkene, a palladium-catalyzed alkyl-Suzuki coupling, an exquisitely selective ring-closing alkyne metathesis, and a ruthenium-catalyzed trans-hydrosilylation tandem.

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