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Jayanta Chatterjee, Dale F. Mierke and Horst Kessler Conformational Preference and Potential Templates of N-Methylated Cyclic Pentaalanine Peptides Chemistry - A European Journal 14

Article first published online: 13 DEC 2007 | DOI: 10.1002/chem.200701029

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Cyclic peptide template structures: The impact of N-methylation on cyclic pentapeptides of the class cyclo(-D-Ala-Ala4-) is described (see figure). We identified a systematic modulation of the conformation by N-methylation. The reported structures can now be employed as templates for the design of bioactive peptides and for “spatial screening”.

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