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Zeyu Xiao, Dihua Shangguan, Zehui Cao, Xiaohong Fang and Weihong Tan Cell-Specific Internalization Study of an Aptamer from Whole Cell Selection Chemistry - A European Journal 14

Article first published online: 18 DEC 2007 | DOI: 10.1002/chem.200701330

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A cell-specific aptamer has been selected through a novel cell selection process (cell-SELEX), in which whole intact cells are used as targets (see scheme) while another related cell line is used as a negative control. The aptamer is specifically internalized into the target cell and transported to a specific intracellular compartment.

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