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Gonzalo Blay, Luis R. Domingo, Victor Hernández-Olmos and José R. Pedro New Highly Asymmetric Henry Reaction Catalyzed by CuII and a C1-Symmetric Aminopyridine Ligand, and Its Application to the Synthesis of Miconazole Chemistry - A European Journal 14

Article first published online: 2 APR 2008 | DOI: 10.1002/chem.200800069

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Enantioselective Henry reaction: A new copper(II) complex with a C1-symmetric chiral aminopyridine ligand catalyzes the asymmetric Henry reaction between nitroalkanes and a broad range of aldehydes (see scheme) to provide the expected nitroalkanols in high yields (up to 99 %) and excellent enantioselectivities (up to 98 %). The reaction has been applied to the enantioselective synthesis of miconazole.

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