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Goutam Biswas, Ock-Youm Jeon, Woo Sirl Lee, Dong-Chan Kim, Kyong-Tai Kim, Suho Lee, Sunghoe Chang and Sung-Kee Chung Novel Guanidine-Containing Molecular Transporters Based on Lactose Scaffolds: Lipophilicity Effect on the Intracellular Organellar Selectivity Chemistry - A European Journal 14

Version of Record online: 3 SEP 2008 | DOI: 10.1002/chem.200801160

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Drug-delivery vehicles: Two lactose-based G7 molecular transporters with different linker chain lengths were synthesized (see scheme, FITC=fluorescein isothiocyanate). They showed good cellular uptake and preferential localization either in mitochondria or in lysosomes and endocytic vesicles, depending on their chain lengths.

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