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Alda Lisa Concia, Carles Lozano, José A. Castillo, Teodor Parella, Jesús Joglar and Pere Clapés D-Fructose-6-phosphate Aldolase in Organic Synthesis: Cascade Chemical-Enzymatic Preparation of Sugar-Related Polyhydroxylated Compounds Chemistry - A European Journal 15

Version of Record online: 16 FEB 2009 | DOI: 10.1002/chem.200802532

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D-Fructose-6-phosphate aldolase (FSA) is a key biocatalyst for the alternative synthetic construction of biologically active products with known therapeutic and research interest or novel structures relevant to drug discovery. Novel aldol addition reactions of dihydroxyacetone and hydroxyacetone to a variety of aldehydes catalyzed by FSA are presented (see scheme).

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