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A. Tamilselvi and Govindasamy Mugesh Hydrolysis of Organophosphate Esters: Phosphotriesterase Activity of Metallo-β-lactamase and Its Functional Mimics Chemistry - A European Journal 16

Article first published online: 23 JUN 2010 | DOI: 10.1002/chem.201000282

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Functional mimics: Binuclear zinc(II) complexes that exhibit good metallo-β-lactamase (mβl) activity are poor mimics of phosphotriesterase (PTE) and vice versa, indicating that the binding of β-lactam substrates at the binuclear zinc(II) center is different to that in phosphotriesters (see scheme). Furthermore, phosphodiesters, the products from the hydrolysis of phosphotriesters, inhibit the PTE activity of mβl and its functional mimics.

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