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Dr. Andrew J. Surman, Dr. Célia S. Bonnet, Dr. Mark P. Lowe, Gavin D. Kenny, Prof. Jimmy D. Bell, Dr. Éva Tóth and Dr. Ramon Vilar A Pyrophosphate-Responsive Gadolinium(III) MRI Contrast Agent Chemistry - A European Journal 17

Version of Record online: 7 DEC 2010 | DOI: 10.1002/chem.201001397

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Pick an anion: The anion-binding properties of functionalised Ln-DTPA-bis-amide complexes (Ln=Gd3+, Eu3+, DTPA=diethylene triamine pentaacetic acid) were investigated by using indicator displacement assays (IDAs) (see picture). A remarkable selectivity for polyphosphorylated species was observed. This has been successfully used to modulate the relaxivity of the Gd3+ complex with pyrophosphate.

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