Dr. Antoine Français, Dr. Antonio Leyva-Pérez, Dr. Gorka Etxebarria-Jardi, Javier Peña and Prof. Dr. Steven V. Ley Total Synthesis of Iso- and Bongkrekic Acids: Natural Antibiotics Displaying Potent Antiapoptotic Properties Chemistry - A European Journal 17
Iso-bong: A versatile first synthesis of isobongkrekic acid (IBA) has been developed. Key steps include three different palladium cross-couplings and an asymmetric homopropargylation. In-depth synthetic studies reveal the challenges faced in generating the right geometry of each diene.
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