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Shobhit Charan, Dr. Fan-Ching Chien, Dr. Narendra Singh, Dr. Chiung-Wen Kuo and Dr. Peilin Chen Development of Lipid Targeting Raman Probes for In Vivo Imaging of Caenorhabditis elegans Chemistry - A European Journal 17

Article first published online: 15 MAR 2011 | DOI: 10.1002/chem.201002896

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A simple, sensitive, and highly specific targeting Raman probe has been developed to image living nematode Caenorhabditis elegans (see picture). Our strategy involves the fabrication of lipid targeting probes, which were incorporated into the intracellular intestinal granules of the C. elegans by incubating with Raman probes, resulting in the uptake of these Raman probes into the intestinal granule, thus allowing fast visualization of lipid droplets through the SERS imaging technique.

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