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Dr. Shiyong Zhang and Prof. Dr. Yan Zhao Oligocholate Foldamers as Carriers for Hydrophilic Molecules across Lipid Bilayers Chemistry - A European Journal 17

Version of Record online: 20 SEP 2011 | DOI: 10.1002/chem.201101510

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Shuttle launch: Oligocholate foldamers adopt helical conformations in nonpolar environments with a hydrophobic exterior and a hydrophilic internal cavity. By switching to such conformations transiently, they can traverse lipid bilayers (see picture) and shuttle hydrophilic guests across. The transport rate can be tuned over a broad range by the conformational properties of the foldamers.

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