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Chenguang Lou, Montserrat Shelbourne, Prof. Keith R. Fox and Prof. Tom Brown 2′-Aminoethoxy-2-amino-3-methylpyridine in Triplex-Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation Chemistry - A European Journal 17

Version of Record online: 30 NOV 2011 | DOI: 10.1002/chem.201102287

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Triplex glue that targets DNA: 2′-Aminoethoxy-2-amino-3-methylpyridine (AE-MAP, see scheme) has been made for the first time and incorporated into triplex-forming oligonucleotides (TFOs). It is a potent triplex stabilizer at high pH and is selective for GC base pairs. TFOs containing AE-MAP do not interact strongly with single stranded DNA. They are highly resistant to nucleases and have potential in gene knock-out studies.

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