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Yunfei Cai, Prof. Dr. Xiaohua Liu, Jun Li, Weiliang Chen, Wentao Wang, Dr. Lili Lin and Prof. Dr. Xiaoming Feng Asymmetric Iodoamination of Chalcones and 4-Aryl-4-oxobutenoates Catalyzed by a Complex Based on Scandium(III) and a N,N′-Dioxide Ligand Chemistry - A European Journal 17

Version of Record online: 8 DEC 2011 | DOI: 10.1002/chem.201102453

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Highly diastereo- and enantioselective iodoamination of chalcones and 4-aryl-4-oxobutenoates, as well as of a trifluoro-substituted enone, in the presence of a chiral complex based on ScIII and a N,N′-dioxide ligand (0.5–2 mol %) has been developed. This method delivers the desired vicinal anti-α-iodo-β-amino products regioselectively with excellent yields and enantioselectivity (see scheme).

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