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Anne-Caroline Chany, Dr. Virginie Casarotto, Dr. Marjorie Schmitt, Prof. Dr. Céline Tarnus, Dr. Laure Guenin-Macé, Dr. Caroline Demangel, Dr. Olivier Mirguet, Prof. Dr. Jacques Eustache and Dr. Nicolas Blanchard A Diverted Total Synthesis of Mycolactone Analogues: An Insight into Buruli Ulcer Toxins Chemistry - A European Journal 17

Article first published online: 30 NOV 2011 | DOI: 10.1002/chem.201102542

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Subtle changes, big impacts! Deciphering the functional interactions of mycolactones is of fundamental importance for the understanding and ultimately the control of Buruli ulcer, a devastating mycobacterial infection. A diverted total-synthesis approach of mycolactone analogues is reported. It provides the first insights into their structure–activity relationship based on cytopathic assays on L929 fibroblasts (see figure).

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