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Dr. Weiqiang Zhan, Dr. Yi Jiang, Shubhada Sharma, Peggy J. Brodie, Prof. Susan Bane, Prof. David G. I. Kingston, Prof. Dennis C. Liotta and Dr. James P. Snyder C6–C8 Bridged Epothilones: Consequences of Installing a Conformational Lock at the Edge of the Macrocycle Chemistry - A European Journal 17

Version of Record online: 30 NOV 2011 | DOI: 10.1002/chem.201102630

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Not quite rigid enough: A series of conformationally restrained epothilone analogues with a short bridge between the methyl groups at C6 and C8 was designed to mimic the binding pose assigned to the recently reported epothilone A–microtubule binding model.

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