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Dr. André Dallmann, Dr. Afaf H. El-Sagheer, Dipl.-Chem. Lars Dehmel, Dr. Clemens Mügge, Prof. Dr. Christian Griesinger, Prof. Dr. Nikolaus P. Ernsting and Prof. Dr. Tom Brown Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained Chemistry - A European Journal 17

Version of Record online: 30 NOV 2011 | DOI: 10.1002/chem.201102979

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Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen (see figure). The results explain the surprising biocompatibility of triazole-linked DNA.

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