Dr. Mei-Jin Li, Dr. Keith Man-Chung Wong, Dr. Changqing Yi and Prof. Vivian Wing-Wah Yam New Ruthenium(II) Complexes Functionalized with Coumarin Derivatives: Synthesis, Energy-Transfer-Based Sensing of Esterase, Cytotoxicity, and Imaging Studies Chemistry - A European Journal 18
Woodruff—not only tasty! Two new bichromophoric ruthenium(II) complexes with appended coumarin ligands have been synthesized. The energy-transfer-based sensing of esterase by the complexes was studied by using UV/Vis and luminescence spectroscopy. The RuII complex containing a coumarin 343 derivative was found to exhibit only a slight cytotoxicity towards HepG2 cells, and it was easily taken up in the living cells to show evident response to the esterase (see figure).
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