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Dr. Bin Tan, Xiaofei Zeng, Wendy Wen Yi Leong, Zugui Shi, Prof. Dr. Carlos F. Barbas III and Prof. Dr. Guofu Zhong Core Structure-Based Design of Organocatalytic [3+2]-Cycloaddition Reactions: Highly Efficient and Stereocontrolled Syntheses of 3,3′-Pyrrolidonyl Spirooxindoles Chemistry - A European Journal 18

Version of Record online: 9 DEC 2011 | DOI: 10.1002/chem.201103449

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Extraordinary levels of stereocontrol were achieved in an efficient organocatalytic asymmetric [3+2]-cycloaddition reaction between an α-isothiocyanato imide and various methyleneindolinones. Simple precursors were used for the rapid construction of spirocyclic oxindole derivatives with high enantiopurity and structural diversity, thus providing a new avenue of significance to medicinal chemistry and diversity-oriented synthesis.

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