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Dr. Johannes Notni, Jakub Šimeček, Prof. Dr. Petr Hermann and Prof. Dr. Hans-Jürgen Wester TRAP, a Powerful and Versatile Framework for Gallium-68 Radiopharmaceuticals Chemistry - A European Journal 17

Article first published online: 6 DEC 2011 | DOI: 10.1002/chem.201103503

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A veritable gallium TRAP: Triazacyclononane-phosphinic acid chelators (TRAP) form highly stable complexes with Ga3+ (see figure) extremely efficiently over a wide pH range. Homo- and heteromultimeric bioconjugates can be synthesized in a straightforward manner, all of which renders TRAP a chelator with ideal properties for 68Ga positron emission tomography (PET) imaging agent elaboration.

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