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Dr. Anja Richter, Dr. Rolf Rose, Dr. Christian Hedberg, Prof. Dr. Herbert Waldmann and Dr. Christian Ottmann An Optimised Small-Molecule Stabiliser of the 14-3-3–PMA2 Protein–Protein Interaction Chemistry - A European Journal 18

Version of Record online: 29 MAR 2012 | DOI: 10.1002/chem.201103761

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Glued together: An initial screening hit that stabilises a 14-3-3 protein–protein interaction has been optimised by means of chemical synthesis. The resulting compound is three-times more active than the initial hit and displays selectivity for the interaction of 14-3-3 proteins with the plant proton pump PMA2 (see figure).

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