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Dr. Rafael Ballesteros-Garrido, Dr. Diane Rix, Dr. Céline Besnard and Prof. Jérôme Lacour Medium-Sized Rings versus Macrocycles through Rhodium-Catalyzed Ring-Expansion Reactions of Cyclic Acetals Chemistry - A European Journal 18

Version of Record online: 11 APR 2012 | DOI: 10.1002/chem.201103870

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Medium rings: α-Diazo β-ketoesters and diketones react with cyclic acetals under RhII catalysis to yield unprecedented polyoxygenated 8- and 9-membered rings in one pot (see scheme). The reactions occur under mild conditions with yields up to 90 %. The medium-sized ring formation and perfect regioselectivity are direct consequences of Baldwin's rules.

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