Dr. Rafael Ballesteros-Garrido, Dr. Diane Rix, Dr. Céline Besnard and Prof. Jérôme Lacour Medium-Sized Rings versus Macrocycles through Rhodium-Catalyzed Ring-Expansion Reactions of Cyclic Acetals Chemistry - A European Journal 18
Medium rings: α-Diazo β-ketoesters and diketones react with cyclic acetals under RhII catalysis to yield unprecedented polyoxygenated 8- and 9-membered rings in one pot (see scheme). The reactions occur under mild conditions with yields up to 90 %. The medium-sized ring formation and perfect regioselectivity are direct consequences of Baldwin's rules.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf