J. Johan Verendel, Jia-Qi Li, Xu Quan, Byron Peters, Taigang Zhou, Dr. Odd R. Gautun, Prof. Thavendran Govender and Prof. Pher G. Andersson Chiral Hetero- and Carbocyclic Compounds from the Asymmetric Hydrogenation of Cyclic Alkenes Chemistry - A European Journal 18
Several types of chiral hetero- and carbocyclic compounds have been synthesized by asymmetric hydrogenation of cyclic alkenes by using N,P-ligated iridium catalysts (see scheme). Six-membered cyclic alkenes were reduced in good to excellent selectivity, whereas the reduction of five-membered cyclic alkenes was generally less selective. The major enantiomer formed could be predicted from a selectivity model and isomeric alkenes gave complementary enantioselectivity.
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