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Andreas F. G. Glawar, Dr. Daniel Best, Benjamin J. Ayers, Saori Miyauchi, Shinpei Nakagawa, Matilde Aguilar-Moncayo, Prof. José M. García Fernández, Prof. Carmen Ortiz Mellet, Dr. Elizabeth V. Crabtree, Dr. Terry D. Butters, Dr. Francis X. Wilson, Prof. Atsushi Kato and Prof. George W. J. Fleet Scalable Syntheses of Both Enantiomers of DNJNAc and DGJNAc from Glucuronolactone: The Effect of N-Alkylation on Hexosaminidase Inhibition Chemistry - A European Journal 18

Article first published online: 26 JUN 2012 | DOI: 10.1002/chem.201200110

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Getting the NAc of it: Scalable syntheses of DGJNAc and DNJNAc from D-glucuronolactone are reported. DGJNAc and its N-alkyl derivatives were inhibitors of α-GalNAcase and both DGJNAc and DNJNAc were potent inhibitors of β-GlcNAcases and β-GalNAcases.

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