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Lu Hao, Feng Wu, Zong-Cang Ding, Su-Xia Xu, Yan-Li Ma, Prof. Dr. Li Chen and Prof. Dr. Zhuang-Ping Zhan Synthesis of Acrylonitriles through an FeCl3-Catalyzed Domino Propargylic Substitution/Aza-Meyer–Schuster Rearrangement Sequence Chemistry - A European Journal 18

Version of Record online: 24 APR 2012 | DOI: 10.1002/chem.201200763

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Nontoxic cyanide source: An unprecedented route to acrylonitriles by employing propargylic alcohols and para-tolylsulfonohydrazide as a combined cyano source has been developed (see scheme). This efficient and practical cyanation reaction proceeds through an FeCl3-catalyzed domino propargylic substitution/aza-Meyer–Schuster rearrangement sequence, the rearrangement process of which is reported for the first time.

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