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Dr. Ke-Rang Wang, Yue-Qing Wang, Hong-Wei An, Jin-Chao Zhang and Prof. Dr. Xiao-Liu Li A Triazatruxene-Based Glycocluster as a Fluorescent Sensor for Concanavalin A Chemistry - A European Journal 19

Article first published online: 10 JAN 2013 | DOI: 10.1002/chem.201200905

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Multivalent glycocluster: A novel triazatruxene-based fluorescent sensor (1) for concanavalin A (Con A), based on specific binding interactions, has been designed and synthesized. Its binding constant with Con A was found to be two orders of magnitude higher than those of monovalent mannose ligands. Most interestingly, a fluorescence enhancement of the triazatruxene-based glycocluster was observed upon binding with Con A because of hydrophobic interactions involving sites close to the triazatruxene moiety (see figure).

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