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Dr. Amy C. Topley, Valerio Isoni, Dr. Thomas A. Logothetis, Dr. Duncan Wynn, Dr. Harry Wadsworth, Dr. Alex M. R. Gibson, Imtiaz Khan, Dr. Neil J. Wells, Prof. Cécile Perrio and Prof. Richard C. D. Brown A Resin-Linker-Vector Approach to Radiopharmaceuticals Containing 18F: Application in the Synthesis of O-(2-[18F]-Fluoroethyl)-L-tyrosine Chemistry - A European Journal 19

Version of Record online: 19 DEC 2012 | DOI: 10.1002/chem.201202474

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Detachable labels: A resin-linker-vector (RLV) strategy has been developed for the radiosynthesis of tracer molecules containing the radionuclide 18F, in which the linker has tosylate-like reactivity. The potential for the application of the 4-alkylphenylsulfonate in practical radiosyntheses has been illustrated herein by the synthesis of the positron-emission tomography radiotracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]-FET; see scheme).

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