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Prof. Lutz F. Tietze, Dr. Michael Müller, Svenia-C. Duefert, Dr. Kianga Schmuck and Dr. Ingrid Schuberth Photoactivatable Prodrugs of Highly Potent Duocarmycin Analogues for a Selective Cancer Therapy Chemistry - A European Journal 19

Version of Record online: 7 DEC 2012 | DOI: 10.1002/chem.201202773

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Retoxification by light: Evaluation of the photochemical properties and the in vitro cytotoxicity in the presence and absence of light revealed for the shown prodrug an excellent suitability for an application in selective cancer therapy. The compound is more than two million times less cytotoxic than the corresponding seco-drug with an IC50=110 fM (see picture).

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