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Dr. Robert C. Simon, Dr. Ferdinand Zepeck and Prof. Dr. Wolfgang Kroutil Chemoenzymatic Synthesis of All Four Diastereomers of 2,6-Disubstituted Piperidines through Stereoselective Monoamination of 1,5-Diketones Chemistry - A European Journal 19

Article first published online: 4 JAN 2013 | DOI: 10.1002/chem.201202793

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Being selective: By applying either an S- or R-stereoselective ω-transaminase, the (S)- or (R)-Δ1-piperideines were accessible through regioselective monoamination of 1,5-diketones (see scheme). Diastereoselective reduction of the optically pure Δ1-piperideines gave access to all four diastereomers of 2,6-dialkylpiperidines.

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