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Dr. Yoshinari Sawama, Yuki Yabe, Hiroki Iwata, Dr. Yuta Fujiwara, Dr. Yasunari Monguchi and Prof. Dr. Hironao Sajiki Stereo- and Regioselective Direct Multi-Deuterium-Labeling Methods for Sugars Chemistry - A European Journal 18

Article first published online: 13 NOV 2012 | DOI: 10.1002/chem.201202852

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Branding sugars: An efficient chemo- and stereoselective synthetic route to multi-deuterated sugars by using non-labeled sugars as starting materials and their Ru/C-catalyzed H–D-exchange reaction in D2O has been developed. The exchange reaction takes place selectively on carbons adjacent to the free hydroxyl groups to perform the deuterium labeling of various pyranosides (such as glucose disaccharide etc.), as well as furanosides, represented by ribose and deoxyribose (see scheme).

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