Karen Stroobants, Eva Moelants, Hong Giang T. Ly, Prof. Dr. Paul Proost, Prof. Dr. Kristin Bartik and Prof. Dr. Tatjana N. Parac-Vogt Polyoxometalates as a Novel Class of Artificial Proteases: Selective Hydrolysis of Lysozyme under Physiological pH and Temperature Promoted by a Cerium(IV) Keggin-Type Polyoxometalate Chemistry - A European Journal 19
It's a snip! Hen-egg-white lysozyme (HEWL) is specifically hydrolyzed at the Trp28–Val29 and Asn44–Arg45 peptide bonds in the presence of a Keggin-type [Ce(α-PW11O39)2]10− polyoxometalate (1) at pH 7.4 and 37 °C (see figure). The reactivity of 1 towards a range of dipeptides was also examined and the calculated reaction rates were comparable to those observed for the hydrolysis of HEWL.
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