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Dr. Filippo Doria, Dr. Matteo Nadai, Dr. Marco Folini, Dr. Matteo Scalabrin, Dr. Luca Germani, Dr. Giovanna Sattin, Prof. Mariella Mella, Prof. Manlio Palumbo, Dr. Nadia Zaffaroni, Dr. Daniele Fabris, Prof. Mauro Freccero and Dr. Sara N. Richter Targeting Loop Adenines in G-Quadruplex by a Selective Oxirane Chemistry - A European Journal 19

Version of Record online: 4 DEC 2012 | DOI: 10.1002/chem.201203097

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Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.

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